Karakterisasi Kitosan Cangkang Kerang Meti (batissa Violacea L. Von Lamark, 1818) Asal Kabupaten Morowali Utara Sebagai Kandidat Biomaterial Dalam Bidang Farmasi

The shells of meti (Batissa violacea L. Von Lamarck, 1818) contain chitin compounds
that need to be modified into chitosan compounds to be used as biomaterial candidates
in the pharmaceutical field such as edible film. The purpose of this study was to
determine the physical characteristics (solubility, viscosity, molecular weight,
morphology and crystallization) of meti mussel shell chitosan (Batissa violacea L.
Von Lamarck, 1818) as a biomaterial candidate in the pharmaceutical field. Isolation
of chitosan through three stages namely deproteination, demineralization and
deacetylation, characterized using Scanning Electron Microscope (SEM), and X-Ray
Diffraction (XRD), physicochemical characterization of methi shell chitosan includes
solubility, viscosity and molecular weight. SEM test characterization shows the
morphology of chitosan has a smooth surface, small size and lump-shaped. XRD
testing shows a diffraction pattern with the main and highest peaks at angles 2? =
23,08 °; 26,18 °; 29,32 ° and 33,13 ° the diffraction pattern confirms the structure
formed is crystalline. The results of physicochemical characterization testing showed
that chitosan was completely soluble in acetic acid with a concentration of 1% and
2%. Viscosity and molecular weight were obtained as 1,08; 1.51; 2,30 cp and 2,3 x
10³; 3,4 x 10³; 5,5 x 10³ kDa, respectively. Based on the results obtained, it can be
concluded that methi mussel shell chitosan has the potential as a biomaterial candidate
in the pharmaceutical field.